Drug Discovery Services

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Discovery Solutions

Home  Solutions Discovery

Pioneering Innovation in Drug Discovery & Development

At PI Health Sciences, we’ve engineered a differentiated “IND generation engine” that transforms concepts into clinical candidates. As your dedicated partner, we combine scientific expertise with operational excellence to create value for biotechs and pharma companies.
Our strength lies in our integrated approach—non-siloed teams of drug hunters, biologists, and chemists working collaboratively. This seamless integration allows us to execute efficiently across all drug discovery phases, from hit validation through candidate nomination.
Our co-located interdisciplinary teams eliminate traditional barriers to innovation, fostering rapid problem-solving and agile responses to evolving project needs.

Backed by world-renowned experts and state-of-the-art technologies including AI-aided drug design, we deliver comprehensive solutions across multiple therapeutic areas with flexible business models that adapt to your specific requirements.
Choose PI Health Sciences to accelerate your path to clinical success with precision and unwavering dedication.

Integrated Drug Discovery

Integrated Drug Discovery

Seamlessly blending biology and chemistry expertise through co-located teams to accelerate your compounds from concept to candidate selection.

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Custom Synthesis and Manufacturing

Pre-clinical Services

Comprehensive evaluation and optimization of drug candidates ensuring safety, efficacy, and regulatory compliance before clinical trials.

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crop solutions

Toxicology Services

Expert assessment of compound safety profiles through specialized studies that identify and mitigate potential risks.

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Chemistry

Discovery Chemistry

Innovative synthetic approaches and medicinal chemistry expertise to design, optimize, and deliver patentable molecules with superior properties.

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Biologicals

Discovery Biology

Advanced screening and validation capabilities that identify promising targets and elucidate mechanisms of action to drive informed development decisions.

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Target ID/Validation
Hit ID
Candidate Optimization
Pre-Clinical Phase
  1. Target selection & characterization​
  2. Target <-> Disease association​
  3. Disease mechanisms​
  4. Model selection and Assay planning
  5. Approach​
  6. Omics (Genomics)​
  7. Pathway analysis​
  8. Knock-in/knock out studies​
In vitro assays:​

  1. Biochemical
  2. Orthogonal ​
  3. HTS formats​

HTS/DEL/Fragments/ Virtual screening​

  1. Library Design/Synthesis​
  2. Hit validation, resynthesis​
  3. Hit Expansion, prioritization

In vitro assays:​

  1. Cellular Mechanistic​
  2. Cellular Functional ​
  3. Relevant off-targets​
  4. In vitro ADME assays​
  5. Protein binding
  6. Metabolism​
  7. CYP inhib/induct

Research operational Plan:​

  1. Assay Priority​
  2. Key Studies​
  3. Critical path

Optimization:​

  1. Biochemical/cell potency​
  2. Selectivity, Phys/Chem properties​
  3. ADME/PK​
  4. In vitro/ In vivo Tool compounds​
  5. Novelty
In vitro safety:​
  1. Herg​
  2. Ion Channels
Later Translational:​

  1. PK/PD/Efficacy​
  2. Refinement of patient selection hypothesis​
  3. Biomarkers

Human Dose Projection​:

  1. h-PK projection​
  2. PK/PD/Efficacy data​
  3. Safety/Tox data

DRF Tox (R/NR)​
Bioanalysis​
GLP Tox (R/NR)​
GLP Bioanalysis​

Our Expert Team

PI Health Sciences brings together world-renowned subject matter experts who guide our drug discovery journey. Our non-siloed structure features high-caliber scientists working collaboratively at the program level—skilled biologists, veteran drug hunters, and accomplished medicinal and synthetic chemists.
Our leadership team delivers deep expertise across Oncology, Immunology, Immuno-Oncology, Neuroscience, and Infectious Diseases, ensuring each project benefits from specialized knowledge and strategic insight.
By eliminating traditional departmental barriers, our interdisciplinary teams share mixed-discipline laboratories, fostering immediate communication and rapid problem-solving. This collaborative environment allows us to adapt quickly to research challenges while maintaining scientific rigor—delivering exceptional results for our partners.

Our Expert Team

PI Health Sciences brings together world-renowned subject matter experts who guide our drug discovery journey. Our non-siloed structure features high-caliber scientists working collaboratively at the program level—skilled biologists, veteran drug hunters, and accomplished medicinal and synthetic chemists.
Our leadership team delivers deep expertise across Oncology, Immunology, Immuno-Oncology, Neuroscience, and Infectious Diseases, ensuring each project benefits from specialized knowledge and strategic insight.
By eliminating traditional departmental barriers, our interdisciplinary teams share mixed-discipline laboratories, fostering immediate communication and rapid problem-solving. This collaborative environment allows us to adapt quickly to research challenges while maintaining scientific rigor—delivering exceptional results for our partners.

Contact Us

Reach out today to discuss how our tailored drug discovery and development expertise can accelerate your program's success.