Enabling Technologies
Redefining Innovation at PI Health Sciences
PI Health Sciences brings together Flow Chemistry and Biocatalysis to enable scalable and sustainable chemical development. Our Flow Chemistry Center of Excellence is equipped with advanced reactor platforms such as Fixed Bed, CSTR, MMRS, and slurry flow systems, supported by a fully automated 1 MT/day pilot plant in Udaipur. This infrastructure allows safe execution of hazardous, high-pressure, and high-temperature reactions, supporting smooth scale-up from early research to GMP-ready manufacturing, including batch-to-flow process optimization through collaboration with Flowid.
Alongside flow chemistry, PI Health Sciences delivers enzyme-driven biocatalysis to support greener and cost-effective manufacturing. Using enzymes such as oxidoreductases, transferases, hydrolases, and lyases, we develop selective and efficient synthetic routes that reduce waste and solvent use. These capabilities are supported by well-equipped laboratories and fermentation infrastructure ranging from 5 L to 200 L, enabling the synthesis of chiral molecules, peptides, and nucleosides.
Together, these capabilities form the foundation of the Enabling Technologies platform at PI Health Sciences. By integrating advanced reactor infrastructure, biocatalytic process design, and digital systems within a single development framework, we help clients address safety, scalability, and sustainability early in process development. This approach reduces downstream risk and enables reliable transition from laboratory development to manufacturing-ready processes.
Our Services
Frequently asked questions
We’re here to help with any questions you have about our plans, supported features, and how our model works.
What role do enabling technologies play in chemical process development?
Enabling technologies support the translation of innovative chemistries into scalable, safe, and sustainable manufacturing processes. At PI Health Sciences, they bridge early process concepts with pilot-scale and GMP-ready execution by addressing efficiency, safety, and environmental impact together.
When should flow chemistry be considered over batch processing?
Flow chemistry is particularly suited for hazardous, high-pressure, or high-temperature reactions, as well as processes requiring precise control and consistent product quality. It is often selected to improve safety, scalability, and throughput compared to traditional batch operations.
How does biocatalysis contribute to sustainable manufacturing?
Biocatalysis enables greener synthesis by using enzymes to achieve high selectivity under mild conditions. This reduces solvent consumption, waste generation, and energy requirements while supporting cost-effective production of complex molecules.
Can PI Health Sciences support scale-up from R&D to GMP manufacturing?
PI Health Sciences supports scale-up through integrated infrastructure, including automated pilot-scale facilities and process optimization expertise. This ensures continuity from laboratory development through pilot validation and readiness for GMP manufacturing.
How are flow chemistry and biocatalysis integrated into development programs?
Technology selection is guided by reaction characteristics, safety considerations, and sustainability goals. Flow chemistry and biocatalysis are applied either independently or in combination to design optimized, scalable processes aligned with regulatory and commercial requirements.
Contact Us
Connect with PI Health Sciences to advance your discovery chemistry services, from hit identification and hit-to-lead optimization to high-quality lead generation grounded in scientific rigor.